Eminent Boston Psychiatrist, Frasier Crane, last seen gracing the bars of Cheers has left his life there to start afresh in Seattle. He now has a spot as a popular radio Psychiatrist, giving him the chance to spread words of wit and wisdom to the masses. He shares his apartment with his retired cop father, Martin, and his father's physical care assistant, Daphne Moon. Add in brother Niles, Eddie the dog, some bizarre situations and plenty of humour and you've got all the ingredients for an excellent show and worthy successor to Cheers.
The series follows James St. Patrick, nicknamed "Ghost", owner of a popular New York City nightclub. In addition, he is a major player in one of the city's biggest illegal drug networks. He struggles to balance these two lives, and the balance topples when he realizes he wants to leave the drug ring in order to support his legitimate business.